Kinetic modeling and comparison of invitro dissolution profiles

Abstract

This review describes that the quantitative analysis of the values obtained in dissolution release tests are easier when mathematical formulas that express the dissolution results as a function of some of the dosage forms characteristics are used. From the theoretical analysis of the occurring process, these mathematic models are derived. In most of the cases the theoretical concept does not exist and some empirical equations have proved to be more appropriate. The dissolved amount of drug is a function of the test time when drug release from solid dosage forms has been described by kinetic models. Some commonly used analytical definitions of the functions are zero order, first order, Hixson–Crowell, Weibull, Higuchi, Baker–Lonsdale, Korsmeyer–Peppas and Hopfenberg models. Other release parameters, such as dissolution time, assay time, dissolution efficacy, difference factor (f1) and similarity factor (f2) can be used to characterize drug release profiles.