Study the efficacy of anti-estrogenic drugs in the treatment of poly cystic ovary induced in female rats by estrogen valerate

Abstract

Polycystic Ovary Syndrome (PCO) is the most common endocrine disorder of women. It was characterized by irregular menstrual cycle chronic anovulation, polycystic ovaries and hyperandrogenism. The study designed to determine the efficacy of clomiphene citrate and tamoxifen in the treatment of PCO induced in rats by estrogen valerate. The level of serum LH and FSH was significantly decrease in PCO untreated group, while estradiol and testosterone levels were increased significantly in comparison with control group. Clomiphene citrate was significantly increased LH and FSH level and significantly decreased estradiol and testosterone level. Although the LH and FSH levels returned to their normal level in comparison with the control, but estradiol and testosterone levels after clomiphene citrate treatment, were still more than that recorded in control group. On the other hand, FSH, LH and estradiol levels were not significantly changed in tamoxifen treated group in comparison with PCO untreated group, while testosterone level was significantly decreased in comparison with PCO untreated group. The diameter of follicles was significantly increased, and the thickness of granulosa was significantly decreased in female rats with PCO induced by estrogen valerate. Follicles appeared to be severely atretic, with low numbers of new follicles and disappearance of corpora lutea. The estrus cycle, hormonal status and ovarian morphology were stored with antiestrogenic drugs especially clomiphene citrate.