Effects of acarbose (with and without corn starch diet) and rosiglitazone on kidney functions in alloxan-induced diabetic rats

Abstract

So far, it has been very difficult to express that any particular antidiabetic drug is more effective in terms of nephroprotection. Present study was conducted to evaluate the potential of rosiglitazone and acarbose in minimizing diabetic nephropathy in type 2 diabetes. 40 Wistar albino rats were divided into 4 groups. Group I was alloxan-treated diabetic control. Groups II, III, IV were treated with acarbose, acarbose along with cooked cornstarch diet and rosiglitazone respectively. Diabetes was induced with single dose of alloxan monohydrate intraperitoneally. After induction drug samples were administered orally and effects were studied on day 7, 15 and 30 for determination of renal functions. Highly significant decrease (p<0.001) in creatinine level after 7 days and then significant increase (p<0.001) was observed after 15 and 30 days in all treated groups. BUN level of groups II and III were significantly decreased (p<0.001) after 7 and 15 days. Group III showed a highly significant (p<0.001) increase after 30 days. Group IV showed an initially elevated BUN level after 7 days. The levels were then decreased after 15 and 30 days. Acarbose use is associated with less risk of drug-induced nephropathy.