Formulation development and in-vitro evaluation of dexlansoprazole loaded double walled microspheres

Authors

  • Rayala Vivek Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India
  • Narender Karra Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India
  • B Raj Kamal Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India

Keywords:

Carbopol, Microspheres, Diffusion, Kinetics, Co-polymers

Abstract

In the present work, double walled microspheres of Dexlansoprazole using Sodium alginate, HPMC E15, Xanthan gum, Ethyl cellulose as copolymers and along with Carbopol were formulated to deliver Dexlansoprazole through oral route. Details regarding the preparation and evaluation of the formulations have been discussed in results. From the study following conclusions could be drawn. The results of this investigation indicate that Ion gelation method can be successfully employed to fabricate Dexlansoprazole microspheres. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymer used. Microspheres containing sodium alginate along with carbopol and HPMC E15 in 1:1.5 ratios had a least size range of 12µm.Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, and Particle size. The invitro drug release decreased with increase in the polymer and copolymer concentration. Among all formulations DL6 shows Maximum drug release in 12th hr  when compared with other formulations. Analysis of drug release mechanism showed that the drug release from the formulations followed the Non fickian diffusion mechanism and follows zero order kinetics. Based on the results of evaluation tests formulation coded DL6 was concluded as best formulation.

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Published

2020-12-22

How to Cite

Rayala Vivek, Narender Karra, & B Raj Kamal. (2020). Formulation development and in-vitro evaluation of dexlansoprazole loaded double walled microspheres. World Journal of Pharmaceutical Sciences, 9(1), 5–10. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/74

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Section

Research Article