Formulation development and in-vitro evaluation of saxagliptin loaded floating microspheres

Abstract

The present study has been a satisfactory attempt to formulate floating microspheres of Saxagliptin, a novel anti- diabetic medicine charitable a CR of the drug. From the investigational consequences it can be completed that, FT-IR was exhibits there is no any important shifting of the peaks so it proven the small phrase constancy of the drug in the beads. Chitosan & albumins are used in    microspheres preparation. Good% drug entrapment & % yields were attaining with together the polymers. Among all preparations were within the limits so, they are easily filled into capsules. % CDR significantly reduced with enhanced in polymer concentration. S7 formulation showing better drug release among remaining formulation drug release for 12 hours was obtained 83.91±3.16% follows First order kinetic model & Higuchi model.