Formulation and evaluation of nanoparticles by emulsification method

Bheemshetty Priyanka; G.S. Sharma; B. Rajkamal; B. Rama; L. Jyothi Rani

Authors

Bheemshetty Priyanka Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India
G.S. Sharma Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India
B. Rajkamal Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India
B. Rama Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India
L. Jyothi Rani Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India

Keywords:

Quetiapine fumarate, Nanoparticles, particle size, SEM, Zeta potential

Abstract

Quetiapine fumarate is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. As biological half life of drug is 6-7 hrs and that is why frequent dosing is require. To overcome with these problems, Nanoparticles of Quetiapine fumarate were formulated by using Ethyl Cellulose, HPMC K4M & Chitosan as a polymer by emulsification method. Among all the 12 formulations QF11 formulation is optimized, as it shows maximum drug release at the end of 12hrs which suits the controlled release drug delivery system criteria as per our studies, having acceptable particle size, SEM and Zeta potential value. From the drug release kinetics of QF11 formulation of Quetiapine fumarate Nanoparticles dispersion it was concluded that the QF11 formulation follows Zero order drug release with super case II transport mechanism.