ESTIMATION OF BEXAGLIFLOZIN BY USING RP-HPLC METHOD

Authors

  • A. Kanaka Durga Valli Assoc.Professor, Srinivasa Rao College of Pharmacy, P.M Palem, Vishakapatnam
  • D. Sai Deepika Department of Pharmaceutical Analysis and Quality Assurance, Srinivasa Rao College of Pharmacy, P.M Palem, Affiliated to Andhra University, Vishakapatnam - 530041, Andhra Pradesh, India.
  • Dr. K. Atchuta Kumar Professor, Srinivasa Rao College of Pharmacy, P.M Palem, Vishakapatnam.

Keywords:

HPLC Bexagliflozin, Method development. ICH Guidelines.

Abstract

A simple, Accurate, precise method was developed for the simultaneous estimation of the An easy, sensitive, specific, and precise RP-HPLC method for determining API and pharmaceutical bexagliflozin. Discovery C18 150 x 4.6 mm, 5m chromatogram analysis. Column was pumped with 0.01N Na2Hpo4: Methanol 55:45 mobile phase at 0.9ml/min. This buffer was 30°C. Selecting 220.0nm optimized wavelength. Bexagliflozin retained 2.854 Min. Method precision was 0.4 and Bexagliflozin's % RSD was 0.9. Bexelifluzin recovered 99.63%. In regression equation, Bexagliflozin LOD and LOQ were 0.440 and 1.33. Bexagliflozin regression equation: y = 2121x + 4049.8 Reduced retention and run times made the method simple and cost-effective for regular quality control tests in industries.

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Published

2024-01-03

How to Cite

A. Kanaka Durga Valli, D. Sai Deepika, & Dr. K. Atchuta Kumar. (2024). ESTIMATION OF BEXAGLIFLOZIN BY USING RP-HPLC METHOD. World Journal of Pharmaceutical Sciences, 11(01). Retrieved from https://wjpsonline.com/index.php/wjps/article/view/1475

Issue

World J Pharm Sci 2023; 11(01): 1-76

Section

Research Article

License

Copyright (c) 2023 A. Kanaka Durga Valli, D. Sai Deepika, Dr. K. Atchuta Kumar

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.