Method Development and Validation of Simultaneous Estimation of Cabotegravir and Rilpivirine Using RP-HPLC Method

Authors

  • L.Swathi Assoc.Professor, Srinivasa Rao College of Pharmacy, P.M Palem, Vishakapatnam.

Keywords:

Cabotegravir, Rilpivirine, RP-HPLC

Abstract

For the simultaneous estimate of Cabotegravir and Rilpivirine in pharmaceutical dose form, a simple, accurate, and exact approach was established. BDS C8 150 x 4.6 mm, 5m chromatogram was done. A mobile phase containing 0.1% orthophosphoric acid:acetonitrile in a 50:50 ratio was pushed down the column at a flow rate of 1.0 ml/min. 0.1% Ortho phosphoric acid buffer was utilized in this procedure. The temperature was kept at 30°C. The optimal wavelength chosen was 257 nm. Cabotegravir and Rilpivirine retention times were determined to be 2.950 min and 3.518.%RSD of Cabotegravir and Rilpivirine were found to be 0.8 and 0.5, respectively. %Cabotegravir and Rilpivirine recovery rates were 99.19% and 98.90%, respectively. LOD and LOQ values derived from regression

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Published

2024-01-03

How to Cite

L.Swathi. (2024). Method Development and Validation of Simultaneous Estimation of Cabotegravir and Rilpivirine Using RP-HPLC Method. World Journal of Pharmaceutical Sciences, 11(02). Retrieved from https://wjpsonline.com/index.php/wjps/article/view/1488

Issue

Section

Research Article