SIMULTANEOUS ESTIMATION OF THE PREGABALIN AND ETORICOXIB IN TABLET DOSAGE FORM BY USING RP-HPLC METHOD

Authors

  • L.Swathi Assoc.Professor, Srinivasa Rao College of Pharmacy, P.M Palem, Vishakapatnam.

Keywords:

Pregabalin, Etoricoxib, RP-HPLC

Abstract

A simple, Accurate, precise method was developed for the simultaneous estimation of the Pregabalin and Etoricoxib in Tablet dosage form. Chromatogram was run through Agilent C18 150 x 4.6 mm, 5m. Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile taken in the ratio 50:50 was pumped through column at a flow rate of 0.8 ml/min. Buffer used in this method was 0.01N KH2PO4 buffer. PH adjusted to 5.4 with dil. Orthophosphoric acid solution. Temperature was maintained at 30°C. Optimized wavelength selected was 240.0 nm. A simple, Accurate, precise method was developed for the simultaneous estimation of the Pregabalin and Etoricoxib in Tablet dosage form. Retention time of Pregabalin and Etoricoxib were found to be at 2.302 min and 3.219 min %RSD of the Pregabalin and Etoricoxib were and found to be 0.5 and 0.6 respectively. %Recovery was obtained as 100.27% and 100.22% for Pregabalin and Etoricoxib respectively. LOD, LOQ values obtained from regression equations of Pregabalin and Etoricoxib were 0.27, 0.83 and 0.24, 0.72 respectively. Regression equation of Pregabalin is y = 23826x + 8530.6 y = 27243x + 3474.3 of Etoricoxib. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.

Downloads

Published

2024-01-03

How to Cite

L.Swathi. (2024). SIMULTANEOUS ESTIMATION OF THE PREGABALIN AND ETORICOXIB IN TABLET DOSAGE FORM BY USING RP-HPLC METHOD. World Journal of Pharmaceutical Sciences, 11(02). Retrieved from https://wjpsonline.com/index.php/wjps/article/view/1483

Issue

Section

Research Article