Synthesis, characterization and antimicrobial activity of some new coumarine derivatives

Abstract

The emergence of microbial strains resistant to the present antibiotics highlights the need for search of new antimicrobial agents. In continuation to this, present work deals with the synthesis and antimicrobial activity of 2 amino-3-(benzo[d] thiazol-2-yl)-4-phenyl pyrano [3,2-c] chromen-5(4H)-one derivatives. The newly synthesized compounds were screened for in vitro antimicrobial activity against four Gram positive bacteria, four Gram negative bacteria and four fungi in the solvent Dimethylsulphoxide. Some of the synthesized compounds exhibited better antibacterial activity against Gram positive bacteria than Gram negative bacteria.  None of the synthesized compounds showed antifungal activity against the selected fungal strains.