Formulation and evaluation of bilayered tablets of sustained release metformin HCl and gliclazide

https://doi.org/10.54037/WJPS.2022.100310

Abstract

The aim of the present work is to formulate and evaluate a bilayered tablet (BT) of Metformin HCl as Sustained release and Gliclazide as Immediate release (IR). The polymer used in sustained release is HMPC K100M and the super disintegrate used in immediate release in proportion of Gum Karaka & Croscarmellose sodium by direct compression method. In this study, a bilayered tablet containing Gliclazide in IRL and Metformin in SRL was made using the wet granulation method, with the goal of making the formulations IRL as small as possible, Will release Gliclazide as soon as possible to combat postprandial hyperglycemic level, followed by steady-state plasma glucose management by Metformin with a long-term release. The hardness of the different formulations ranged from 7.5-8.5 kg/cm. All the formulations exhibited less than1% friability. The drug content analysis of Metformin and Gliclazide in all formulations was found within the IP limits (±5%) which indicate that the drug was uniformly distributed in the tablets. The inviter dissolution study was performed for layer I (Metformin) up to 12 hrs (after every 1hour intervals) and for layer II (Gliclazide) up to 40 min (after every 5 min interval). The bilayered tablet contributing initial loading dose and dissolves rapidly, the remainder of the drug in the extended release was constant rate till the end of the dissolution process. The I.R spectra proved that there was no interaction between the polymer, Excipients and Metformin, Gliclazide.